3-month Schizophrenia Drug: Invega Trinza

The superstar of antipsychotic medications has arrived… The first 3-month injectable antipsychotic medication has dosing in seasons, not days or months. Invega Trinza (paliperidone palmitate) by Janssen Pharmaceuticals is administered once every three months – that’s only 4 times per year!

Invega Trinzia is a paradigm shift in the treatment of patients with Schizophrenia. This allows patients to regain control of their life and improve their independence, rather than focusing on the disruptions involved with their medication schedule. It is also beneficial for patients that have good resolution of symptoms when compliant with oral Invega but have trouble with medication compliance.


1) Invega: daily oral tablet

So, a little background… Oral Invega (paliperidone), the once-daily oral tablet, was created in 2006 as the new and improved version of Risperdal (risperidone) without the side effects of excessive weight gain and gynecomastia.


2) Invega Sustenna: monthly injection

After this, Invega Sustenna (paliperidone palmitate) was created as a once-monthly injectable antipsychotic with no need to take a daily oral tablet. In my experience, many people with schizophrenia that didn’t like to take daily oral medications found resolution of symptoms for one month, after which they would usually decompensate.


3) Invega Trinza: three-month injection

Invega Trinza (paliperidone palmitate), a three-month injection, is an atypical antipsychotic indicated for the treatment of schizophrenia in patients after they have been adequately treated with Invega Sustenna for at least four months. Invega Trinza is not to be used to treat dementia-related psychosis.

Invega Trinza comes in four doses: 273 mg, 410 mg, 546 mg and 819 mg. If the patient has been adequately treated with Invega Sustenna 156mg IM qmonth, this dose would be correlated with Invega Trinza 546mg IM q 3-months.


By Dr. Terra Caudill, MD, MS


*This is a personal opinion and is not meant for, nor should replace, any medical or psychiatric advice. Consult your physician and psychiatrist for any medical advice to be used in the treatment of patients. Full prescribing information from the manufacturer should be referenced including https://www.invegatrinzahcp.com/